Quick Facts

  • FDA approved treatment for Peyronie’s disease
  • Targets the Peyronie’s plaque directly
  • Quick outpatient procedure

Xiaflex Doctors


Xiaflex Therapy for Peyronie’s Disease
Peyronie’s disease, or curvature of the penis due to scar tissue (or Peyronie’s plaque), can be a source of pain and discomfort. It can lead to erectile dysfunction, shortening of the penis, and pain during an erection. One treatment option is Xiaflex, which is the first FDA-approved treatment for Peyronie’s

Xiaflex is injected directly into the scar tissue or plaque. Gentle stretching and straightening of the penis after the injection helps reduce curvature. Multiple injections over the course of several weeks are usually necessary to achieve the desired results.

Xiaflex is a treatment option for men who have both a bump of scar tissue that can be felt and a curved erection of at least 30 degrees.

How does Xiaflex work?
Xiaflex is a medication called collagenase clostridium histolyticum. It actively targets the Peyronie’s plaque to break it down. While the fibers in the plaque are being broken down, manual stretching and straightening help the penis to regain a more normal shape and decrease the degree of curvature.

How is Xiaflex injected?
Xiaflex is injected by a specially trained urologist or urology healthcare professional during an outpatient office visit. A small amount of the medication is injected into the plaque. The procedure is quick and relatively painless.

What side effects are associated with Xiaflex?
As with any medication, there are possibilities of side effects. These can include mild swelling, bruising, or pain at the site of injection. It is possible for serious injury or a penile fracture to occur with Xiaflex treatment.

Occasionally, back pain can happen suddenly, which usually disappears after around 15 minutes or so. Allergic reactions including anaphylaxis are possible.

Next Steps

Schedule an appointment with your provider to discuss if Xiaflex is an appropriate treatment option for you.

Frequently Asked Questions

How much does Xiaflex cost?
Many insurance companies cover the cost of treatment for Peyronie’s disease, as it is considered a significant medical problem. Contact your insurance provider directly to find out if they will cover Xiaflex treatment.

Xiaflex offers a payment assistant program for those that meet certain eligibility criteria.

Is Xiaflex FDA approved?
Yes – Xiaflex is the first treatment for Peyronie’s disease that is FDA approved.

Is Xiaflex safe?
Yes – Xiaflex is approved by the FDA, which means it has been studied for safety and efficacy (how well it works). Like any medical treatment or procedure, there are some risks. Pain, swelling, and bruising at the injection site are most common. Serious injury or penile fracture is possible and requires immediate medical attention. Allergic reactions are possible as well.

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